Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. The etiology of salivary gland tumors sgts remains mostly unknown. Cetuximab in the treatment of metastatic mucoepidermoid. All patients received surgery as the primary treatment modality with or. Sep 28, 2017 the parotid glands, the largest salivary glands, are just in front of the ears. Mucoepidermoid carcinoma is a rare primary thyroid tumor with indolent biologic potential. Prior reports noted histological grade and tumor stage as consistently important prognostic factors. The system proposed by auclair and goode is useful, and our data lend further support to its application and validity in clinical practice. The 75 % of tumors was located in the great salivary glands, the 56.
Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Salivary glands neoplasms represent a rare and diverse group of tumors with different characteristics. Lowgrade mucoepidermoid carcinoma of the intraoral. It can mimic most other tumors of the glands, and therefore is often considered in the differential. Pdf intraoral mucoepidermoid carcinoma of salivary glands.
Pdf mucoepidermoid carcinoma of minor salivary glands. The second most common minor salivary gland tumour 1240% globally is mucoepidermoid carcinoma. Jul 21, 20 mucoepidermoid carcinoma mec, one of the most common salivary gland malignancies, is rare in children. These tumors in the major salivary glands constitutes around 53% and parotid gland is affected most frequently 45%, followed by the minor. Mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland. Mucicarmine staining is one stain used by pathologist for detection.
Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Mucoepidermoid carcinoma is a tumor that usually occurs in the salivary glands. Mucoepidermoid carcinoma an overview sciencedirect topics. Histocytologic grading of mucoepidermoid carcinoma of major. Mucoepidermoid carcinoma occurred in the parotid gland in 196 cases. Mucoepidermoid carcinoma in a minor salivary gland in a child.
Proliferating cell nuclear antigen expression in mucoepidermoid. Mucoepidermoid carcinoma mec is the most common malignancy of the major salivary glands. The early diagnosis and the correct management of this neoplasm are key factors for the prognosis. Of these, mucoepidermoid carcinoma mec is the most common, representing 30% to 40% of all salivary. In the salivary glands, the most frequently occurring benign tumor is pleomorphic adenoma, and the most frequent malignant tumor is mucoepidermoid carcinoma mc. Most of these tumors are benign not cancer, but the parotid glands still are where most malignant cancerous salivary gland tumors start. Salivary glands make saliva, which aids in digestion, keeps your mouth moist and supports healthy teeth. It can also occur in other organs such as the thyroid, bronchi and lacrimal sac. Original article prognostic factors in mucoepidermoid. The large number of histological types of tumors in salivary glands makes them a very. The age of the patients ranged between 7 and 84 years. Lowgrade mucoepidermoid carcinoma of salivary glands. Although mucoepidermoid carcinoma mec accounts for of all tumors of the salivary gland, it constitutes approximately 30% of all malignant tumors of the salivary gland. They develop less often in the submandibular glands or in minor salivary glands inside the mouth.
The original report of mucoepidermoid tumors in 1945. Cancer in the salivary gland is called salivary gland cancer. They affect the intraoral major and minor salivary glands in more than 90% of the cases 1, 2. Mucoepidermoid carcinoma of the major salivary glands. It is an aggressive lesion and must be considered as a diagnosis hypothesis in the oral mucosa proliferative lesions. Salivary gland neoplasms account for approximately 5% of head and neck neoplasms, but fewer than 1% of malignancies in all body sites. It is an aggressive lesion and must be considered as a diagnosis hypothesis in the oral. Mucoepidermoid carcinoma of the minor salivary gland. However, the palate is a frequent site when it occurs in the minor glands. Nov 29, 2018 a mucoepidermoid carcinoma mec of salivary gland is a type of malignant glandular epithelial tumor affecting either the major or minor salivary glands. Role of radiotherapy for mucoepidermoid carcinoma of salivary gland. Pdf mucoepidermoid carcinoma of the salivary glands.
Introduction the mucoepidermoid carcinomas mec represent about 5% of all tumors in the salivary glands. Oct 26, 2018 salivary gland tumors can begin in any of the salivary glands in your mouth, neck or throat. Prognostic factors in mucoepidermoid carcinoma of the. Mucoepidermoid carcinoma of floor of the mouth a rarity ncbi. We report the case of a 72yearold malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid. Intraoral mucoepidermoid carcinoma of salivary glands. Mucoepidermoid carcinoma mucoepidermoid carcinomas are the most common type of salivary gland cancer. Jul 29, 2016 in the salivary glands, the most frequently occurring benign tumor is pleomorphic adenoma, and the most frequent malignant tumor is mucoepidermoid carcinoma mc. Mucoepidermoid carcinoma is the most frequent malignant tumor of the salivary glands in children. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Mucoepidermoid carcinoma what is, treatment, survival rate. Mucoepidermoid carcinoma of the salivary glands clinical. Mucoepidermoid carcinomas mecas are salivary gland tumors that involve the major and minor sali vary glands with a strong predilection for the parotid. Salivary gland tumors symptoms and causes mayo clinic.
Thirtyone of the mucoepidermoid tumors were in major salivary glands. The purpose of this study was to evaluate the clinical outcomes of mec of minor salivary glands in a group of 16 patients, who were treated in our clinic, and to discuss the management of this carcinoma. Mucoepidermoid carcinoma is the most common malig nant lesion of the major and minor salivary glands. Majority of the salivary gland tumors arise in parotid gland with maximum.
Mucoepidermoid carcinoma mec, one of the most common primary. To analyze the patterns of failure and factors affecting recurrence and overall survival in mucoepidermoid carcinoma of the salivary gland. Mucoepidermoid carcinoma genetic and rare diseases. The infrequency of reports of mucoepidermoid carcinoma of the subglottis, and of the larynx in general, may be attributable to the relative difficulty that physicians have in recognizing this tumor type when it occurs outside the salivary glands.
Mec mainly occurs in the parotid gland, along with minor glands being the second common site, particularly in palate. Mucoepidermoid carcinoma is the most common malignant tumor of salivary gland. Mucoepidermoid carcinoma variants adenoid cystic carcinoma carcinoma ex pleomorphic adenoma salivary duct carcinoma mucoepidermoid carcinoma incidence most common malignant salivary gland tumor children and adults major and minor salivary glands p k i id 5th t 6th d d 36 peak incidence 5th to 6th decades. Mucoepidermoid carcinoma mec is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor. Mucoepidermoid carcinoma of the soft palate salivary gland.
Major salivary glands were involved in 46 cases 44 parotid, two submandibular, and intraoral minor glands in 23. Mucoepidermoid carcinoma mec is the most common malignant primary salivary gland tumor and is composed of a mixture of mucous, intermediate, and epidermoid squamoid cells 33. Mucoepidermoid carcinoma of the major salivary glands goode. Aug 01, 2014 the second most common minor salivary gland tumour 1240% globally is mucoepidermoid carcinoma. Two types of tumors have been described under this category. Mucoepidermoid carcinoma of intraoral salivary glands. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in the parotid gland. Mucoepidermoid carcinoma of the salivary glands in brazil. About salivary gland cancer what is salivary gland cancer. In 1945, stewart and colleagues introduced the term mucoepidermoid to define. Current state of knowledge on salivary gland cancers ncbi. Minor salivary gland tumours account for 1015% of all salivary gland neoplasms and are usually malignant. The tumors are formed by aggregates of squamous and mucin secretory cells and are classified histologically as high, intermediate, or low grade.
Pdf lowgrade mucoepidermoid carcinoma of salivary glands. Jun 18, 20 mucoepidermoid carcinoma is a type of cancer of the salivary glands. However it can present in the minor salivary glands, especially in the soft palate. Patients diagnosed as mucoepidermoid carcinoma of the salivary gland were eligible for analysis. Mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands among children and adults and shows a wide, nearly uniform age distribution, with diminution in pediatric and geriatric life. Among the major salivary glands, mec occurs most frequently in the parotid gland. Mucoepidermoid carcinoma mec of the salivary gland is a rare entity. Pdf role of radiotherapy for mucoepidermoid carcinoma of. Clinical, histological, and radiological findings of palatal mec in a 12yearold girl are presented with threeyear followup. These cancers are usually low grade, but they can also be intermediate or high grade.
Mucoepidermoid carcinoma is a malignant epithelial tumour of glandular tissue, usually of the major salivary glands. Mucoepidermoid carcinomas in the major salivary glands were scored and graded. Cetuximab in the treatment of metastatic mucoepidermoid carcinoma of the salivary glands. In 1895, volkman described these tumors for first time. Epidemiology mucoepidermoid carcinomas are seen throughout all. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. A rare case of mucoepidermoid carcinoma of parotid with. You have three pairs of major salivary glands under and behind your jaw parotid, sublingual and submandibular. Mucoepidermoid carcinoma of the salivary gland sciencedirect. Mucoepidermoid carcinoma the oral cancer foundation. Cords, sheets and clusters of mucous, squamous, intermediate and clear cells. Mucoepidermoid carcinoma mec is the most common malignant neoplasm of major and minor salivary glands and can also occur as an intraosseous tumor frequently called as central mec. Mucoepidermoid carcinoma mec can have a variety of clinical outcomes, but prognosis seems to be related to the tumor grade.
Lack of association among clinicopathological features and immunoexpression of cerbb2 in 29. Mucoepidermoid carcinoma is an unusual variant of thymic carcinoma characterized by the admixture of squamous and glandular, mucinsecreting elements, similar to their salivary gland counterparts. Sixtynine cases of mucoepidermoid carcinoma with a minimum of five years followup are presented. It is observed in a wide age category of children and adults. Approximately 80% of parotid gland tumors are benign. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. About 7 out of 10 salivary gland tumors start here. The hospital records were retrospectively analyzed from october 2010 to january 2016. Mc is defined as a malignant epithelial neoplasm of the salivary glands that represents 3040 % of all malignant neoplasms of the salivary glands.
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